Orgasm and antidepressants

Problems reaching orgasm can be caused by not enough dopamine or its receptors. Sexual dysfunction is observed in 30-50% of people taking selective serotonin reuptake inhibitors (SSRIs): citalopram, sertraline, paroxetine, fluoxetine - a group of third-generation antidepressants. These medications can reduce the production of dopamine, a neurotransmitter that provides pleasurable feelings and regulates the reward circuitry—keeps the person wanting to do the pleasurable act again. It cannot be said that orgasm directly depends on dopamine, since after the abolition of SSRIs, when the level of dopamine returns to normal, in some patients, sexual dysfunction persists for a long time. However, dopamine definitely plays a big role in achieving orgasm.