Sperm Donor with Rare Cancer Mutation Fathers 67 Children in Europe

A sperm donor with a rare cancer mutation became the father of 67 children in 8 European countries - 10 of whom developed cancer. The TP53 gene identified in the donor's sperm is associated with Li-Fraumeni syndrome - a rare hereditary condition that significantly increases cancer risk. The mutation was not detected by standard methods at the time of sperm donation (2008-2015). Later, 23 children inherited the same mutation, and 10 developed cancerous diseases, including leukemia and lymphoma.